Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
insulin signaling pathway
|
| gptkbp:clinical_trial |
gptkb:Oncology
cardiovascular diseases insulin resistance |
| gptkbp:code |
insulin receptor substrate 1 protein
|
| gptkbp:has_expression_pattern |
varies with diet
downregulated in diabetes upregulated in obesity |
| gptkbp:has_function |
phosphorylation
signal transduction protein binding |
| gptkbp:has_role |
cell differentiation
cell growth |
| gptkbp:has_variants |
SNPs
|
| https://www.w3.org/2000/01/rdf-schema#label |
IRS1
|
| gptkbp:interacts_with |
insulin receptor
|
| gptkbp:involved_in |
glucose metabolism
|
| gptkbp:is_associated_with |
aging
oxidative stress inflammatory response |
| gptkbp:is_expressed_in |
liver
muscle tissue adipose tissue |
| gptkbp:is_involved_in |
apoptosis
cardiac function cell cycle regulation immune response lipid metabolism protein synthesis wound healing muscle development cellular response to stress cell survival neurogenesis tissue repair neuroprotection bone metabolism vascular function cellular response to growth factor stem cell differentiation fertility regulation cellular response to insulin |
| gptkbp:is_linked_to |
metabolic syndrome
obesity type 2 diabetes |
| gptkbp:is_part_of |
MAPK signaling pathway
insulin signaling complex PI3 K signaling pathway |
| gptkbp:is_regulated_by |
gptkb:diabetes
IGF-1 |
| gptkbp:is_studied_in |
endocrinology
genetic research pharmacogenomics |
| gptkbp:located_in |
human chromosome 2
|
| gptkbp:orthologs |
IRS1 in mice
IRS1 in rats IRS1 in zebrafish |
| gptkbp:targets |
therapeutic interventions
antidiabetic drugs |
| gptkbp:bfsParent |
gptkb:PIK3_CA
|
| gptkbp:bfsLayer |
6
|