|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
insulin resistance
|
|
gptkbp:discoveredBy
|
Morris White
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
gptkb:PH_domain
PTB domain
multiple tyrosine phosphorylation sites
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000169047
|
|
gptkbp:fullName
|
Insulin receptor substrate 1
|
|
gptkbp:function
|
signal transduction
insulin signaling pathway
|
|
gptkbp:gene
|
gptkb:IRS1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0007165
GO:0008286
GO:0005158
|
|
gptkbp:HGNC_ID
|
HGNC:6125
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IRS1
|
|
gptkbp:interactsWith
|
gptkb:insulin_receptor
gptkb:PI3K
gptkb:Grb2
SH2 domain-containing proteins
|
|
gptkbp:length
|
1,238 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
2q36.3
|
|
gptkbp:molecularWeight
|
131 kDa
|
|
gptkbp:mutationAssociatedWith
|
insulin resistance
impaired glucose tolerance
|
|
gptkbp:OMIM
|
147545
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Irs1
|
|
gptkbp:PDB
|
1IRS
|
|
gptkbp:phosphorylates
|
gptkb:tyrosine
serine
|
|
gptkbp:RefSeq
|
NM_005544
|
|
gptkbp:regulates
|
gptkb:insulin
cytokines
growth factors
|
|
gptkbp:tissue_specificity
|
gptkb:skeletal_muscle
liver
adipose tissue
pancreas
|
|
gptkbp:UniProtID
|
P35568
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT/mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|