|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:AICAR
gptkb:metformin
gptkb:AMP
|
|
gptkbp:alternativeName
|
gptkb:AMPK_alpha-1
gptkb:AMPK_catalytic_subunit_alpha-1
|
|
gptkbp:associatedWith
|
AMPK signaling pathway
|
|
gptkbp:component
|
gptkb:AMP-activated_protein_kinase_complex
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:AMP-activated_protein_kinase_catalytic_subunit_alpha-1
|
|
gptkbp:Entrez_Gene_ID
|
5562
ENSG00000132356
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
|
|
gptkbp:function
|
regulation of cellular energy homeostasis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_006251
NM_145331
|
|
gptkbp:HGNC_ID
|
9381
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PRKAA1
|
|
gptkbp:inhibitedBy
|
gptkb:compound_C
|
|
gptkbp:lengthOfProtein
|
548 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
|
|
gptkbp:molecularWeight
|
62 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:type_2_diabetes
obesity
|
|
gptkbp:numberOfExons
|
12
|
|
gptkbp:OMIM
|
602739
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Prkaa1
|
|
gptkbp:phosphorylates
|
gptkb:CaMKKβ
gptkb:LKB1
|
|
gptkbp:product
|
gptkb:AMPK_alpha-1_subunit
|
|
gptkbp:regulates
|
glucose uptake
autophagy
fatty acid oxidation
mTOR signaling
|
|
gptkbp:relatedTo
|
gptkb:cancer
gptkb:cardiovascular_disease
apoptosis
cell growth
energy metabolism
insulin sensitivity
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:UniProtID
|
gptkb:Q13131
|
|
gptkbp:bfsParent
|
gptkb:AMPK_pathway
gptkb:AMPK
|
|
gptkbp:bfsLayer
|
6
|