cytochrome P450, family 3, subfamily A, polypeptide 4

URI: https://gptkb.org/entity/cytochrome_P450,_family_3,_subfamily_A,_polypeptide_4
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:CYP3A4
P450-3A
cytochrome P450 3A4
gptkbp:EC_number 1.14.14.1
gptkbp:encodedBy gptkb:CYP3A4_gene
gptkbp:expressedIn gptkb:kidney
gptkb:small_intestine
brain
liver
colon
gptkbp:family gptkb:cytochrome_P450
gptkbp:foundIn intestine
human liver
gptkbp:function drug metabolism
steroid metabolism
xenobiotic metabolism
gptkbp:gene gptkb:CYP3A4
gptkbp:HGNC_ID 2623
https://www.w3.org/2000/01/rdf-schema#label cytochrome P450, family 3, subfamily A, polypeptide 4
gptkbp:inducedBy gptkb:phenytoin
gptkb:rifampin
gptkb:carbamazepine
gptkb:St._John's_wort
gptkbp:inhibitedBy gptkb:milk
gptkb:clarithromycin
gptkb:ketoconazole
gptkbp:locatedIn gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome 7
7q22.1
gptkbp:molecularWeight 57 kDa
gptkbp:OMIM 124010
gptkbp:pathway gptkb:steroid_hormone_biosynthesis
drug metabolism - cytochrome P450
metabolism of xenobiotics by cytochrome P450
gptkbp:PDB 1TQN
gptkbp:polypeptide 4
gptkbp:RefSeq NM_017460
gptkbp:species gptkb:Homo_sapiens
gptkbp:subfamily 3A
gptkbp:substrate gptkb:cyclosporine
gptkb:erythromycin
gptkb:midazolam
statins
testosterone
gptkbp:UniProtID P08684
gptkbp:bfsParent gptkb:Cytochrome_P450_3A4
gptkb:CYP3A4_gene
gptkbp:bfsLayer 6