|
gptkbp:instance_of
|
gptkb:Fullmetal_Alchemist
|
|
gptkbp:administered_by
|
intravenous injection
|
|
gptkbp:approves
|
gptkb:FDA
|
|
gptkbp:can_be_combined_with
|
gptkb:docetaxel
gptkb:paclitaxel
gptkb:pembrolizumab
gptkb:methotrexate
gptkb:cisplatin
gptkb:etoposide
gptkb:nivolumab
gptkb:cladribine
gptkb:carfilzomib
gptkb:carboplatin
gptkb:gemcitabine
gptkb:bortezomib
gptkb:cyclophosphamide
gptkb:lenalidomide
gptkb:irinotecan
gptkb:oxaliplatin
gptkb:trastuzumab
gptkb:thalidomide
gptkb:ifosfamide
bevacizumab
decitabine
temozolomide
azacitidine
bleomycin
dactinomycin
fludarabine
adriamycin
topotecan
|
|
gptkbp:casnumber
|
865-21-4
|
|
gptkbp:chemical_formula
|
C46 H58 N4 O9
|
|
gptkbp:class
|
Vinca alkaloid
|
|
gptkbp:contraindication
|
pregnancy
severe liver disease
|
|
gptkbp:developed_by
|
Vinca rosea
|
|
gptkbp:discovered_by
|
gptkb:1958
Robert Noble
|
|
gptkbp:excretion
|
bile
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
vinblastine
|
|
gptkbp:interacts_with
|
gptkb:CYP3_A4
|
|
gptkbp:lifespan
|
approximately 24 hours
|
|
gptkbp:mass
|
825.99 g/mol
|
|
gptkbp:mechanism_of_action
|
inhibits microtubule formation
|
|
gptkbp:replaces
|
periwinkle plant
|
|
gptkbp:side_effect
|
nausea
constipation
hair loss
bone marrow suppression
|
|
gptkbp:targets
|
dividing cells
|
|
gptkbp:trade
|
Velban
|
|
gptkbp:used_for
|
treating cancer
|
|
gptkbp:used_in
|
combination chemotherapy
|
|
gptkbp:bfsParent
|
gptkb:vincristine
|
|
gptkbp:bfsLayer
|
7
|