vinblastine

URI: https://gptkb.org/entity/vinblastine

GPTKB entity

Statements (47)

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound antineoplastic agent vinca alkaloid
gptkbp:ATCCode	L01CA01
gptkbp:CASNumber	143-67-9
gptkbp:chemicalFormula	C46H58N4O9
gptkbp:derivedFrom	gptkb:Catharanthus_roseus
gptkbp:discoveredBy	gptkb:Charles_Thomas_Beer gptkb:Robert_Noble
gptkbp:discoveredIn	1958
gptkbp:drugClass	antimitotic agent
gptkbp:eliminationHalfLife	19-24 hours
gptkbp:foundIn	gptkb:Madagascar_periwinkle
gptkbp:hasSMILES	CC[C@@H]1CN2CC[C@]3(C)[C@H]4CC[C@@]5(O)C(=O)N(C)C(=O)[C@H]6C[C@@H](C(=O)OC)N(C)C(=O)[C@H]6[C@H]5[C@H]4[C@H]3[C@H]2[C@H]1C
https://www.w3.org/2000/01/rdf-schema#label	vinblastine
gptkbp:IUPACName	methyl (1S,9S,10R,12R,13S,17S,18R,19R)-17-ethyl-10-(methoxycarbonyl)-13,19-dimethyl-7,15-dioxa-4,21-diazahexacyclo[11.7.1.0^{1,9}.0^{2,7}.0^{9,18}.0^{13,21}]henicosa-2,4,6,8,11,16-hexaene-12-carboxylate
gptkbp:KEGGID	D08668
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits microtubule formation
gptkbp:MeSH_ID	D014757
gptkbp:metabolism	liver
gptkbp:molecularWeight	810.98 g/mol
gptkbp:origin	natural product
gptkbp:pregnancyCategory	D (US)
gptkbp:PubChem_CID	gptkb:CHEMBL521 21106260 241903 DB00570
gptkbp:relatedTo	gptkb:vincristine gptkb:vindesine gptkb:vinorelbine
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	nausea vomiting constipation hair loss peripheral neuropathy bone marrow suppression
gptkbp:UNII	6T6UO836M8
gptkbp:usedFor	gptkb:cancer gptkb:Kaposi's_sarcoma gptkb:Hodgkin's_lymphoma gptkb:non-Hodgkin's_lymphoma testicular cancer
gptkbp:bfsParent	gptkb:CYP3A4_gene gptkb:Catharanthus_roseus
gptkbp:bfsLayer	6