|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MKK3
gptkb:MEK3
gptkb:PRKMK3
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammatory response
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108984
5606
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_3
|
|
gptkbp:function
|
Serine/threonine-protein kinase involved in MAPK signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:MAP2K3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K3
|
|
gptkbp:inhibitedBy
|
gptkb:BIRB796
gptkb:SB203580
|
|
gptkbp:interactsWith
|
gptkb:MAP3K12
gptkb:MAP3K1
gptkb:TAOK2
gptkb:MAP3K10
gptkb:MAP3K11
gptkb:MAP3K13
gptkb:MAP3K14
gptkb:MAP3K15
gptkb:MAP3K16
gptkb:MAP3K17
gptkb:MAP3K18
gptkb:MAP3K19
gptkb:MAP3K2
gptkb:MAP3K20
gptkb:MAP3K21
gptkb:MAP3K22
gptkb:MAP3K23
gptkb:MAP3K24
gptkb:MAP3K25
gptkb:MAP3K26
gptkb:MAP3K27
gptkb:MAP3K28
gptkb:MAP3K29
gptkb:MAP3K3
gptkb:MAP3K30
gptkb:MAP3K31
gptkb:MAP3K32
gptkb:MAP3K33
gptkb:MAP3K34
gptkb:MAP3K35
gptkb:MAP3K36
gptkb:MAP3K37
gptkb:MAP3K38
gptkb:MAP3K39
gptkb:MAP3K4
gptkb:MAP3K40
gptkb:MAP3K41
gptkb:MAP3K43
gptkb:MAP3K44
gptkb:MAP3K45
gptkb:MAP3K46
gptkb:MAP3K47
gptkb:MAP3K48
gptkb:MAP3K49
gptkb:MAP3K5
gptkb:MAP3K50
gptkb:MAP3K6
gptkb:MAP3K7
gptkb:MAP3K8
gptkb:MAP3K9
MAP3K42
|
|
gptkbp:length
|
347 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
17
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Map2k3
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:phosphorylates
|
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
gptkb:MAPK14
Ser189
Ser207
Thr193
Thr222
|
|
gptkbp:regulates
|
activated by phosphorylation
MAPK11 activity
MAPK12 activity
MAPK13 activity
MAPK14 activity
|
|
gptkbp:relatedTo
|
apoptosis
cell differentiation
stress response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P46734
|
|
gptkbp:bfsParent
|
gptkb:p38_MAPK_pathway
|
|
gptkbp:bfsLayer
|
6
|