p38 mitogen-activated protein kinases
GPTKB entity
Statements (39)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
environmental stress
pro-inflammatory cytokines dual phosphorylation on threonine and tyrosine residues |
| gptkbp:alsoKnownAs |
gptkb:MAPK_p38
gptkb:Mitogen-activated_protein_kinase_14 |
| gptkbp:biologicalProcess |
serine/threonine kinase activity
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:encodedBy |
gptkb:MAPK14_gene
|
| gptkbp:hasIsoform |
MAPK11 (p38β)
MAPK12 (p38γ) MAPK13 (p38δ) MAPK14 (p38α) |
| https://www.w3.org/2000/01/rdf-schema#label |
p38 mitogen-activated protein kinases
|
| gptkbp:involvedIn |
apoptosis
cell differentiation inflammatory response cellular response to stress |
| gptkbp:involves |
gptkb:cancer
neurodegenerative diseases rheumatoid arthritis |
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:memberOf |
gptkb:MAPK_family
|
| gptkbp:orthologIn |
gptkb:human
gptkb:mouse right |
| gptkbp:phosphorylates |
transcription factors
cytoskeletal proteins protein kinases |
| gptkbp:regulates |
cell proliferation
gene expression cell migration immune response cell cycle cytokine production |
| gptkbp:target |
gptkb:p38_inhibitors
|
| gptkbp:bfsParent |
gptkb:p38_MAPK_pathway
|
| gptkbp:bfsLayer |
6
|