|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:TNF-alpha
gptkb:TGF-beta
gptkb:interleukin-1
|
|
gptkbp:alias
|
gptkb:MAP3K7
gptkb:MEKK7
gptkb:TGF-beta_activated_kinase_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
apoptosis
inflammation
immune response
|
|
gptkbp:discoveredBy
|
gptkb:Shibuya_et_al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
6885
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.25
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:TAB1
gptkb:TAB2
gptkb:TAB3
|
|
gptkbp:fullName
|
gptkb:Transforming_growth_factor-beta-activated_kinase_1
|
|
gptkbp:function
|
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MAP3K7
|
|
gptkbp:HGNC_ID
|
6857
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TAK1
|
|
gptkbp:inhibitedBy
|
gptkb:5Z-7-oxozeaenol
gptkb:NG-25
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:NF-κB_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
6q15
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
cardiomyopathy
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:2EVA
|
|
gptkbp:phosphorylates
|
gptkb:IKK_complex
gptkb:MKKs
Ser192
Thr187
|
|
gptkbp:regulates
|
cell differentiation
cell survival
inflammatory response
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
O43318
|
|
gptkbp:bfsParent
|
gptkb:p38_MAPK_pathway
|
|
gptkbp:bfsLayer
|
6
|