Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:associatedWith |
autoimmune diseases
rheumatoid arthritis autoinflammatory syndromes |
| gptkbp:discoveredIn |
1970s
|
| gptkbp:family |
gptkb:IL-1_family
|
| gptkbp:fullName |
gptkb:Interleukin-1
|
| gptkbp:function |
mediates inflammatory response
induces fever stimulates T cell activation |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-1
|
| gptkbp:includes |
gptkb:IL-1α
gptkb:IL-1β |
| gptkbp:inducedBy |
leukocyte adhesion
endothelial activation prostaglandin synthesis |
| gptkbp:inhibitedBy |
gptkb:IL-1_receptor_antagonist
|
| gptkbp:locatedOnChromosome |
chromosome 2
|
| gptkbp:producedBy |
macrophages
monocytes |
| gptkbp:promotion |
acute phase protein production
|
| gptkbp:recipient |
gptkb:IL-1_receptor
|
| gptkbp:structure |
gptkb:protein
|
| gptkbp:target |
gptkb:canakinumab
gptkb:anakinra |
| gptkbp:bfsParent |
gptkb:p38_MAPK_pathway
gptkb:interleukin-1 gptkb:human_interleukin-6 |
| gptkbp:bfsLayer |
6
|