|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:p38_MAPK
gptkb:MAPK1/ERK2
gptkb:MAPK3/ERK1
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammatory diseases
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:encodedBy
|
gptkb:MKNK1_gene
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.1
|
|
gptkbp:fullName
|
gptkb:MAP_kinase-interacting_serine/threonine-protein_kinase_1
|
|
gptkbp:function
|
protein serine/threonine kinase activity
involved in regulation of translation
phosphorylates eIF4E
|
|
gptkbp:gene
|
gptkb:MKNK1
|
|
gptkbp:GOProcess
|
regulation of translation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MNK1
|
|
gptkbp:inhibitedBy
|
gptkb:CGP57380
|
|
gptkbp:interactsWith
|
gptkb:MAPK1
gptkb:MAPK3
gptkb:p38_MAPK
gptkb:eIF4G
|
|
gptkbp:locatedOnChromosome
|
1q32.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~48 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
mRNA translation regulation
|
|
gptkbp:phosphorylates
|
gptkb:eIF4E
Serine 209 on eIF4E
|
|
gptkbp:structure
|
contains protein kinase domain
|
|
gptkbp:UniProtID
|
Q9BUB5
|
|
gptkbp:bfsParent
|
gptkb:p38_MAPK_pathway
|
|
gptkbp:bfsLayer
|
6
|