|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alternativeName
|
gptkb:TNF
gptkb:cachectin
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
ulcerative colitis
psoriasis
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:fullName
|
gptkb:Tumor_Necrosis_Factor_alpha
|
|
gptkbp:function
|
induces apoptosis
induces inflammation
mediates septic shock
regulates immune cells
stimulates acute phase reaction
|
|
gptkbp:gene
|
gptkb:TNF
|
|
gptkbp:HGNC_ID
|
11892
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF-alpha
|
|
gptkbp:inhibitedBy
|
gptkb:thalidomide
corticosteroids
anti-TNF antibodies
|
|
gptkbp:involvedIn
|
apoptosis
autoimmune diseases
cell signaling
septic shock
inflammation
immune response
cachexia
necrosis
fever induction
tumor regression
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.3
|
|
gptkbp:membraneBoundForm
|
yes
|
|
gptkbp:molecularWeight
|
17 kDa (monomer)
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:PDB
|
gptkb:2AZ5
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:secretes
|
soluble protein
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:p38_MAPK_pathway
gptkb:Enbrel
gptkb:human_interleukin-6
|
|
gptkbp:bfsLayer
|
6
|