|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
phosphorylation
|
|
gptkbp:alias
|
gptkb:ISGF-3
gptkb:STAT91
gptkb:Signal_Transducer_and_Activator_of_Transcription_1-alpha/beta
|
|
gptkbp:alternativeSplicing
|
produces STAT1α and STAT1β isoforms
|
|
gptkbp:associatedWith
|
gptkb:STAT1_deficiency
gptkb:chronic_mucocutaneous_candidiasis
immunodeficiency
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Darnell_Jr.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
gptkb:STAT1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000115415
6772
|
|
gptkbp:fullName
|
gptkb:Signal_transducer_and_activator_of_transcription_1
|
|
gptkbp:function
|
transcription factor
DNA binding
regulates immune response
mediates cellular responses to interferons
transcription regulatory region DNA binding
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
immune response
response to interferon-gamma
|
|
gptkbp:HGNC_ID
|
11362
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT1
|
|
gptkbp:interactsWith
|
gptkb:JAK2
gptkb:JAK1
gptkb:STAT2
gptkb:IFNGR1
gptkb:IFNAR1
gptkb:IRF9
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q32.2
|
|
gptkbp:molecularWeight
|
87 kDa
|
|
gptkbp:OMIM
|
600555
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Stat1
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:Interferon_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1YVL
|
|
gptkbp:phosphorylates
|
gptkb:Ser727
Tyr701
|
|
gptkbp:RefSeq
|
gptkb:NM_007315
|
|
gptkbp:UniProtID
|
gptkb:P42224
|
|
gptkbp:bfsParent
|
gptkb:p38_MAPK_pathway
|
|
gptkbp:bfsLayer
|
6
|