|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
cytokines
growth factors
mitogens
|
|
gptkbp:alsoKnownAs
|
gptkb:MAPK/ERK_pathway
gptkb:Ras-Raf-MEK-ERK_pathway
|
|
gptkbp:component
|
gptkb:Raf_kinase
gptkb:Ras_protein
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:downstreamOf
|
gptkb:integrins
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
transcriptional activation
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
developmental disorders
|
|
gptkbp:ERK1/2Phosphorylates
|
transcription factors
cytoskeletal proteins
other kinases
|
|
gptkbp:fourthComponent
|
gptkb:ERK1/2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK pathway
|
|
gptkbp:importantFor
|
gptkb:pharmacy
cell biology
oncology research
|
|
gptkbp:inhibitedBy
|
gptkb:MEK_inhibitors
ERK inhibitors
Raf inhibitors
|
|
gptkbp:involves
|
gptkb:ERK1/2
gptkb:MEK1/2
gptkb:Raf_kinase
gptkb:Ras_protein
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
gene expression
cell cycle progression
|
|
gptkbp:relatedTo
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:studiedIn
|
gptkb:yeast
mouse models
human cells
|
|
gptkbp:thirdComponent
|
gptkb:MEK1/2
|
|
gptkbp:bfsParent
|
gptkb:MAPK_signaling_pathway
gptkb:p38_MAPK_pathway
gptkb:MAP_kinase_pathway
|
|
gptkbp:bfsLayer
|
6
|