|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TNF-alpha
gptkb:TNFA
gptkb:cachectin
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Crohn's_disease
autoimmune diseases
psoriasis
septic shock
inflammation
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodes
|
gptkb:tumor_necrosis_factor
|
|
gptkbp:Entrez_Gene_ID
|
7124
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11892
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tnf
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:length
|
233 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
6p21.33
|
|
gptkbp:molecularWeight
|
25.6 kDa
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Tnf
|
|
gptkbp:product
|
TNF protein
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:JNK_pathway
gptkb:NF-kappaB_pathway
immune response
AP-1 pathway
caspase pathway
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:transcriptionFactorBinding
|
gptkb:SP1
gptkb:NF-kappaB
gptkb:AP-1
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|