|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:diabetes_mellitus
gptkb:insulinoma
hyperinsulinemia
|
|
gptkbp:biologicalProcess
|
regulation of blood glucose
|
|
gptkbp:chain
|
A chain: 90-110
B chain: 25-54
|
|
gptkbp:discoveredBy
|
gptkb:Frederick_Banting
gptkb:Charles_Best
gptkb:James_Collip
gptkb:John_Macleod
|
|
gptkbp:discoveredIn
|
1921
|
|
gptkbp:EC_number
|
3.4.23.-
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000250971
|
|
gptkbp:expressedIn
|
gptkb:islets_of_Langerhans
|
|
gptkbp:function
|
regulation of glucose metabolism
|
|
gptkbp:gene
|
gptkb:INS
|
|
gptkbp:GO_term
|
GO:0005158 (insulin receptor binding)
GO:0005179 (hormone activity)
GO:0006006 (glucose metabolic process)
|
|
gptkbp:HGNC_ID
|
HGNC:6081
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P01375
|
|
gptkbp:InterPro
|
gptkb:IPR022352
|
|
gptkbp:KEGGID
|
gptkb:hsa:3630
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
11
|
|
gptkbp:molecularWeight
|
11793 Da
|
|
gptkbp:name
|
gptkb:Insulin
|
|
gptkbp:OMIM
|
176730
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Ins2
rat Ins2
|
|
gptkbp:PDB
|
gptkb:1TRZ
gptkb:2HIU
4EY1
|
|
gptkbp:postTranslationalModification
|
disulfide bond
cleavage on pair of basic residues
|
|
gptkbp:predecessor
|
proinsulin
|
|
gptkbp:proteinFamily
|
gptkb:PF00049
|
|
gptkbp:PubChem_CID
|
DB00030
CHEMBL1201560
|
|
gptkbp:Reactome
|
gptkb:R-HSA-264876
|
|
gptkbp:RefSeq
|
gptkb:NP_000198.1
|
|
gptkbp:sequence
|
110
|
|
gptkbp:signalPeptide
|
1-24
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:tissue_specificity
|
pancreas
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|