tumor necrosis factor alpha

URI: https://gptkb.org/entity/tumor_necrosis_factor_alpha
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf cytokine
gptkbp:abbreviation gptkb:TNF-α
gptkbp:alternativeName gptkb:TNFA
gptkb:tumor_necrosis_factor
gptkb:TNF
gptkb:cachectin
gptkbp:associatedWith gptkb:Crohn's_disease
psoriasis
rheumatoid arthritis
ankylosing spondylitis
gptkbp:biosynthesized_from transmembrane protein
gptkbp:category gptkb:cachectin
signaling molecule
immune system protein
apoptosis inducer
pro-inflammatory cytokine
pyrogen
gptkbp:cleaved_by gptkb:TACE_(ADAM17)
gptkbp:discoveredBy gptkb:Lloyd_J._Old
1975
gptkbp:encodedBy gptkb:TNF_gene
gptkbp:ensembl_id ENSG00000232810
gptkbp:function induces apoptosis
induces fever
regulates immune cells
mediates inflammation
inhibits tumorigenesis
gptkbp:gene gptkb:TNF
gptkbp:gene_id 7124
gptkbp:homolog_in_mouse gptkb:Tnf
gptkbp:homolog_in_rat gptkb:Tnf
https://www.w3.org/2000/01/rdf-schema#label tumor necrosis factor alpha
gptkbp:locatedOnChromosome gptkb:6p21.3
gptkbp:molecularWeight 17 kDa (monomer)
gptkbp:OMIM_id 191160
gptkbp:pdb_id gptkb:1TNF
gptkbp:producedBy gptkb:natural_killer_cells
gptkb:T_cells
macrophages
gptkbp:recipient gptkb:TNFR1
gptkb:TNFR2
gptkbp:regulates gptkb:NF-κB_pathway
cell survival
cell death
gptkbp:structure homotrimer
gptkbp:targetOfDrug gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
gptkbp:UniProtID gptkb:P01375
gptkbp:bfsParent gptkb:Remicade
gptkb:Simponi
gptkb:Macrophage
gptkbp:bfsLayer 5