tumor necrosis factor alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cytokine
gptkbp:abbreviation	gptkb:TNF-α
gptkbp:alternativeName	gptkb:TNFA gptkb:tumor_necrosis_factor gptkb:TNF gptkb:cachectin
gptkbp:associatedWith	gptkb:Crohn's_disease psoriasis rheumatoid arthritis ankylosing spondylitis
gptkbp:biosynthesized_from	transmembrane protein
gptkbp:category	gptkb:signaling_molecule gptkb:cachectin immune system protein apoptosis inducer pro-inflammatory cytokine pyrogen
gptkbp:cleaved_by	gptkb:TACE_(ADAM17)
gptkbp:discoveredBy	gptkb:Lloyd_J._Old 1975
gptkbp:encodedBy	gptkb:TNF_gene
gptkbp:ensembl_id	ENSG00000232810
gptkbp:function	induces apoptosis induces fever regulates immune cells mediates inflammation inhibits tumorigenesis
gptkbp:gene	gptkb:TNF
gptkbp:gene_id	7124
gptkbp:homolog_in_mouse	gptkb:Tnf
gptkbp:homolog_in_rat	gptkb:Tnf
gptkbp:locatedOnChromosome	gptkb:6p21.3
gptkbp:molecularWeight	17 kDa (monomer)
gptkbp:OMIM_id	191160
gptkbp:pdb_id	gptkb:1TNF
gptkbp:producedBy	gptkb:natural_killer_cells gptkb:T_cells macrophages
gptkbp:recipient	gptkb:TNFR1 gptkb:TNFR2
gptkbp:regulates	gptkb:NF-κB_pathway cell survival cell death
gptkbp:structure	homotrimer
gptkbp:targetOfDrug	gptkb:etanercept gptkb:infliximab gptkb:adalimumab
gptkbp:UniProtID	gptkb:P01375
gptkbp:bfsParent	gptkb:Cytokine_Release_Syndrome gptkb:Remicade gptkb:Simponi gptkb:Humira
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	tumor necrosis factor alpha