Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:activatedBy |
stress
pro-inflammatory cytokines free radicals antigens ultraviolet irradiation bacterial and viral infections |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:virus neurodegenerative diseases autoimmune diseases inflammatory diseases |
| gptkbp:database |
Gene Ontology:GO:0006355
HGNC:7794 MeSH:D016149 UniProt:P19838 |
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
NFKB1 gene
NFKB2 gene REL gene RELA gene RELB gene |
| gptkbp:foundIn |
eukaryotes
|
| https://www.w3.org/2000/01/rdf-schema#label |
NF-kappaB
|
| gptkbp:inhibitedBy |
IκB proteins
|
| gptkbp:locale |
cytoplasm (inactive)
nucleus (active) |
| gptkbp:regulates |
apoptosis
cell proliferation cell survival inflammation immune response cytokine production DNA transcription |
| gptkbp:regulationMechanism |
phosphorylation
ubiquitination proteasomal degradation IκB degradation nuclear translocation |
| gptkbp:subunit |
RelA (p65)
RelB c-Rel NF-κB1 (p50, p105) NF-κB2 (p52, p100) |
| gptkbp:targetGene |
gptkb:Bcl-2
gptkb:ICAM-1 gptkb:IL-1 gptkb:TNF-alpha gptkb:MHC_class_II gptkb:MHC_class_I gptkb:COX-2 gptkb:VCAM-1 gptkb:MMP9 gptkb:IL-6 iNOS |
| gptkbp:bfsParent |
gptkb:Tnf
gptkb:SOD2 gptkb:CREB-binding_protein gptkb:PRKCI gptkb:TIS8 |
| gptkbp:bfsLayer |
7
|