|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD120a
gptkb:TNF-R1
gptkb:TNF_receptor_superfamily_member_1A
p55
|
|
gptkbp:associatedWith
|
gptkb:familial_Mediterranean_fever
gptkb:TRAPS_(TNF_receptor-associated_periodic_syndrome)
autoimmune diseases
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
1990
|
|
gptkbp:domain
|
death domain
|
|
gptkbp:encodedBy
|
gptkb:TNFRSF1A_gene
|
|
gptkbp:expressedIn
|
many tissues
immune cells
|
|
gptkbp:fullName
|
gptkb:Tumor_necrosis_factor_receptor_1
|
|
gptkbp:function
|
involved in inflammation
activates NF-κB pathway
binds tumor necrosis factor alpha (TNF-α)
mediates apoptosis
|
|
gptkbp:gene
|
gptkb:TNFRSF1A
|
|
gptkbp:HGNC_ID
|
11916
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFR1
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:TRADD
gptkb:TRAF2
gptkb:RIPK1
gptkb:SODD
|
|
gptkbp:ligand
|
gptkb:TNF-α
gptkb:lymphotoxin-alpha
|
|
gptkbp:locatedOnChromosome
|
12p13.2
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
191190
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:1EXT
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:structure
|
extracellular cysteine-rich domains
intracellular death domain
single transmembrane domain
|
|
gptkbp:type
|
gptkb:MAPK_pathway
gptkb:NF-κB_pathway
apoptosis pathway
|
|
gptkbp:UniProtID
|
P19438
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|