|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD120b
gptkb:TNFBR
gptkb:Tumor_necrosis_factor_receptor_superfamily_member_1B
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:binds
|
gptkb:TNF-alpha
gptkb:TNF-beta
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:domain
|
extracellular domain
transmembrane domain
cytoplasmic domain
|
|
gptkbp:encodedBy
|
gptkb:TNFRSF1B_gene
|
|
gptkbp:expressedIn
|
neurons
endothelial cells
immune cells
|
|
gptkbp:fullName
|
gptkb:Tumor_necrosis_factor_receptor_2
|
|
gptkbp:function
|
regulates apoptosis
regulates cell survival
mediates immune response
|
|
gptkbp:gene
|
gptkb:TNFRSF1B
|
|
gptkbp:hasPolymorphism
|
gptkb:M196R
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFR2
|
|
gptkbp:interactsWith
|
gptkb:TRAF2
gptkb:TRAF1
gptkb:cIAP1
gptkb:cIAP2
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.22
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
approximately 75 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Tnfrsf1b
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
gptkb:NF-kappaB_pathway
|
|
gptkbp:PDB
|
gptkb:3ALQ
|
|
gptkbp:regulates
|
inflammation
Treg cell function
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
gptkb:P20333
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|