|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:abbreviation
|
gptkb:TNF
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:cachectin
|
|
gptkbp:associatedWith
|
psoriasis
septic shock
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
7124
|
|
gptkbp:family
|
gptkb:tumor_necrosis_factor_superfamily
|
|
gptkbp:function
|
apoptosis induction
induction of inflammation
inhibition of tumorigenesis
inhibition of viral replication
regulation of immune cells
|
|
gptkbp:gene
|
gptkb:TNF_gene
|
|
gptkbp:HGNC_ID
|
11892
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tumor necrosis factor
|
|
gptkbp:inhibitedBy
|
anti-TNF drugs
|
|
gptkbp:involvedIn
|
apoptosis
autoimmune diseases
cell signaling
septic shock
cachexia
necrosis
chronic inflammation
host defense
fever induction
acute phase reaction
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:MeSH_ID
|
D016133
|
|
gptkbp:molecularWeight
|
17 kDa (monomer)
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:targetOfDrug
|
autoimmune diseases
inflammatory diseases
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|