|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:TNFA
gptkb:tumor_necrosis_factor_alpha
gptkb:cachectin
TNFSF2
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
asthma
ulcerative colitis
psoriasis
septic shock
rheumatoid arthritis
ankylosing spondylitis
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodes
|
tumor necrosis factor protein
|
|
gptkbp:Entrez_Gene_ID
|
7124
ENSG00000232810
GC06M031946
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:fullName
|
gptkb:tumor_necrosis_factor
|
|
gptkbp:function
|
immune system regulation
apoptosis regulation
inflammatory response
cytokine activity
|
|
gptkbp:HGNC_ID
|
gptkb:TNF
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF gene
|
|
gptkbp:length
|
233 amino acids
|
|
gptkbp:locatedOnChromosome
|
6
6p21.33
|
|
gptkbp:molecularWeight
|
25.6 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered immune response
increased susceptibility to autoimmune diseases
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Tnf
|
|
gptkbp:pathway
|
gptkb:TNF_signaling_pathway
apoptosis pathway
NF-kB signaling pathway
|
|
gptkbp:product
|
gptkb:TNF-alpha
|
|
gptkbp:proteinFamily
|
gptkb:tumor_necrosis_factor_superfamily
|
|
gptkbp:regulates
|
regulated by NF-kB
induced by infection
induced by inflammation
|
|
gptkbp:significance
|
biomarker for inflammation
target of anti-TNF therapy
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|