|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:cachectin
|
|
gptkbp:associatedWith
|
gptkb:cancer
sepsis
autoimmune disease
inflammatory bowel disease
|
|
gptkbp:biologicalProcess
|
cell proliferation
septic shock
immune response
cell death
fever induction
|
|
gptkbp:cleavage
|
soluble TNF
|
|
gptkbp:cleavageEnzyme
|
gptkb:TACE_(ADAM17)
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:Entrez_Gene_ID
|
21926
ENSMUSG00000024401
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:T_cells
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:fullName
|
gptkb:Tumor_Necrosis_Factor
|
|
gptkbp:function
|
inflammatory response
cytokine activity
apoptosis induction
|
|
gptkbp:gene
|
gptkb:Tnf
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse TNF
|
|
gptkbp:locatedOnChromosome
|
17
|
|
gptkbp:location
|
gptkb:cell_membrane
secreted
|
|
gptkbp:molecularWeight
|
25.6 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
gptkb:rat_TNF
human TNF
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
NF-kappaB signaling
apoptosis pathway
|
|
gptkbp:postTranslationalModification
|
cleavage
glycosylation
|
|
gptkbp:proteinFamily
|
TNF superfamily
|
|
gptkbp:recipient
|
gptkb:TNFRSF1A
gptkb:TNFRSF1B
|
|
gptkbp:regulates
|
regulated by NF-kappaB
upregulated by LPS
|
|
gptkbp:sequence
|
235
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:UniProtID
|
P06804
|
|
gptkbp:bfsParent
|
gptkb:TNF
|
|
gptkbp:bfsLayer
|
7
|