|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:virus
gptkb:tumor_necrosis_factor_alpha
gptkb:interleukin-1
stress
cytokines
free radicals
antigens
UV irradiation
bacterial products
|
|
gptkbp:alsoKnownAs
|
gptkb:NF-κB_pathway
|
|
gptkbp:component
|
gptkb:IκBα
p50
p52
IKKα
IKKβ
RelA (p65)
RelB
c-Rel
NEMO (IKKγ)
|
|
gptkbp:database
|
KEGG: hsa04064
Reactome: R-HSA-975871
|
|
gptkbp:discoveredBy
|
gptkb:David_Baltimore
Ranjan Sen
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
chronic inflammation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NF-kappaB pathway
|
|
gptkbp:inhibitedBy
|
gptkb:glucocorticoids
anti-inflammatory drugs
IκB proteins
|
|
gptkbp:involves
|
gptkb:IKK_complex
IκB proteins
NF-kappaB transcription factors
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:mechanismOfAction
|
DNA binding
IκB degradation
gene transcription activation
NF-kappaB nuclear translocation
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
inflammation
immune response
|
|
gptkbp:bfsParent
|
gptkb:Tnf
gptkb:PKC_iota
gptkb:PKC_zeta
gptkb:CD284
gptkb:TNFR2
gptkb:TNF_receptor_superfamily
|
|
gptkbp:bfsLayer
|
7
|