|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:cachectin
|
|
gptkbp:biologicalProcess
|
septic shock
immune response
cell death
fever induction
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:Entrez_Gene_ID
|
24835
ENSRNOG00000006310
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:T_cells
macrophages
|
|
gptkbp:fullName
|
gptkb:Tumor_Necrosis_Factor
|
|
gptkbp:function
|
induces apoptosis
mediates inflammation
proinflammatory cytokine
|
|
gptkbp:gene
|
gptkb:Tnf
|
|
gptkbp:GO_term
|
GO:0005125 (cytokine activity)
GO:0006954 (inflammatory response)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
rat TNF
|
|
gptkbp:inhibitedBy
|
gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
|
|
gptkbp:locatedOnChromosome
|
chromosome 20
|
|
gptkbp:location
|
secreted
cell membrane (precursor)
|
|
gptkbp:molecularWeight
|
17 kDa (mature form)
25 kDa (precursor)
|
|
gptkbp:organism
|
gptkb:Rattus_norvegicus
|
|
gptkbp:orthologIn
|
gptkb:mouse_TNF
human TNF
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
NF-kappaB signaling
apoptosis pathway
|
|
gptkbp:recipient
|
gptkb:TNFRSF1A
gptkb:TNFRSF1B
|
|
gptkbp:RefSeq
|
NP_036721.1
|
|
gptkbp:sequence
|
protein sequence available in UniProt P16599
|
|
gptkbp:significance
|
sepsis
autoimmune diseases
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:UniProtID
|
P16599
|
|
gptkbp:bfsParent
|
gptkb:TNF
|
|
gptkbp:bfsLayer
|
7
|