|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:TNF-alpha
gptkb:cachectin
TNFSF2
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000232810
|
|
gptkbp:fullName
|
Tumor Necrosis Factor Alpha
|
|
gptkbp:function
|
cytokine activity
regulates immune cells
proinflammatory cytokine
mediates systemic inflammation
|
|
gptkbp:gene
|
gptkb:TNF
|
|
gptkbp:GOProcess
|
apoptotic process
inflammatory response
|
|
gptkbp:HGNC_ID
|
11892
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFA
|
|
gptkbp:inducedBy
|
gptkb:Bacteria
gptkb:interleukin-1
lipopolysaccharide
|
|
gptkbp:inhibitedBy
|
gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.3
|
|
gptkbp:medicalUse
|
biomarker for inflammation
therapeutic target in autoimmune diseases
|
|
gptkbp:molecularWeight
|
17 kDa
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
apoptosis pathway
NF-kappa B signaling pathway
|
|
gptkbp:PDB
|
gptkb:1TNF
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:RefSeq
|
NM_000594
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell death
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:target
|
anti-TNF therapy
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|