|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:Wilms_tumor
gptkb:cancer
gptkb:medulloblastoma
gptkb:chronic_myeloid_leukemia
gptkb:acute_myeloid_leukemia
gptkb:endometrial_cancer
gptkb:glioblastoma
gptkb:head_and_neck_squamous_cell_carcinoma
gptkb:rhabdomyosarcoma
gptkb:retinoblastoma
gptkb:Ewing_sarcoma
colorectal cancer
leukemia
melanoma
multiple myeloma
pancreatic cancer
prostate cancer
pluripotency
bladder cancer
eye development
cellular reprogramming
stem cell maintenance
osteosarcoma
hepatocellular carcinoma
gastric cancer
pituitary adenoma
renal cell carcinoma
anophthalmia
microphthalmia
esophageal squamous cell carcinoma
lung squamous cell carcinoma
testicular germ cell tumor
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:SRY-box_transcription_factor_2
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000181449
6657
|
|
gptkbp:expressedIn
|
embryonic stem cells
neural stem cells
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:hasDNABindingDomain
|
gptkb:HMG_box
|
|
gptkbp:HGNC_ID
|
11195
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOX2
|
|
gptkbp:interactsWith
|
gptkb:NANOG
gptkb:OCT4
|
|
gptkbp:locatedOnChromosome
|
3q26.3-q27
|
|
gptkbp:memberOf
|
gptkb:SOX_gene_family
|
|
gptkbp:mutationAssociatedWith
|
SOX2 anophthalmia syndrome
|
|
gptkbp:OMIM
|
184429
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Gallus_gallus
gptkb:Mus_musculus
|
|
gptkbp:regulates
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
gptkb:FGF_signaling_pathway
gptkb:Hedgehog_signaling_pathway
gptkb:FGF4
gptkb:POU5F1
apoptosis
cell differentiation
cell proliferation
embryonic development
cell migration
cell cycle
neurogenesis
lung development
maintenance of pluripotency
hair follicle development
LEFTY1
UTF1
astrocyte development
esophageal epithelium
glial cell fate
lens development
olfactory epithelium development
pituitary development
progenitor cell maintenance
self-renewal of stem cells
taste bud development
tracheal epithelium
|
|
gptkbp:UniProtID
|
gptkb:P48431
|
|
gptkbp:usedIn
|
regenerative medicine
cell fate determination
induced pluripotent stem cell generation
|
|
gptkbp:bfsParent
|
gptkb:SOX_gene
gptkb:SOX_proteins
gptkb:Sry-related_HMG-box_(SOX)_gene_family
|
|
gptkbp:bfsLayer
|
6
|