Statements (150)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
pluripotency
Stem cells |
| gptkbp:diseases |
gptkb:Oncology
|
| gptkbp:function |
Regulates pluripotency
regulation of embryonic development |
| gptkbp:genetic_studies |
infertility
anophthalmia Certain cancers |
| gptkbp:has_function |
Maintains stem cell identity
|
| gptkbp:has_role |
gptkb:Oncology
neurogenesis |
| https://www.w3.org/2000/01/rdf-schema#label |
SOX2
|
| gptkbp:initiated_by |
gptkb:Differentiation
|
| gptkbp:interacts_with |
gptkb:Oct4
gptkb:OCT4 gptkb:NANOG |
| gptkbp:involved_in |
Development
neural development |
| gptkbp:is_associated_with |
gptkb:Embryonic_carcinoma
Neural crest cells retinal development Pluripotency cancer stem cells endocrine disorders |
| gptkbp:is_co-expressed_with |
gptkb:NANOG
|
| gptkbp:is_essential_for |
Embryonic development
Retinal development Spermatogenesis Neural crest development Neural differentiation Neural stem cell maintenance Oligodendrocyte development maintenance of pluripotency |
| gptkbp:is_expressed_in |
Embryonic stem cells
testis Lung tissue placenta Bone marrow Placenta Adult tissues bladder salivary glands Adipose tissue Pancreatic tissue Testis adult tissues retina hair follicles neural crest cells Skin cells adrenal glands cornea esophagus mammary glands lung development embryonic stem cells prostate Salivary glands early embryogenesis Cardiac tissue Cervical tissue Early embryogenesis Endometrial tissue Germline cells Neural tissues Ovarian tissue gonadal tissues ovarian follicles |
| gptkbp:is_involved_in |
gptkb:spermatogenesis
gptkb:neurodegenerative_diseases Hematopoiesis Cell proliferation cell differentiation Organogenesis Tumorigenesis muscle development bone development Cell survival Bone development organogenesis tissue repair neuroprotection lens development Muscle development Tissue regeneration Kidney development cell fate determination kidney development germ cell development cardiac development epithelial-mesenchymal transition pancreatic development skin development gastrointestinal development Adrenal gland development Cardiogenesis Cell fate determination Esophageal development Gastric development Germ cell development Intestinal development Liver development Pancreatic development Skin development Thymus development Thyroid development intestinal development ovarian development thyroid development ureter development |
| gptkbp:is_linked_to |
gptkb:Oncology
gptkb:Colorectal_cancer Breast cancer Lung cancer Metastasis Prostate cancer Neurodegenerative diseases schizophrenia Bladder cancer neurodevelopmental disorders autism spectrum disorders Endocrine tumors Head and neck cancer hypopituitarism Reprogramming of somatic cells |
| gptkbp:is_part_of |
stem cell niche
Gene regulatory network Transcriptional regulatory network transcription factor network |
| gptkbp:is_regulated_by |
transcription factors
Epigenetic modifications Transcription factors signaling pathways Micro RNAs |
| gptkbp:is_studied_in |
Stem cell research
regenerative medicine |
| gptkbp:is_targeted_at |
gptkb:CRISPR_technology
Gene therapy Therapeutic agents |
| gptkbp:located_in |
gptkb:Atom
chromosome 3 |
| gptkbp:promoter |
SOX2 gene
|
| gptkbp:regulates |
Self-renewal
self-renewal of stem cells |
| gptkbp:requires |
neural stem cell maintenance
|
| gptkbp:role |
Neurogenesis
|
| gptkbp:targets |
gptkb:RNA_Polymerase
|
| gptkbp:bfsParent |
gptkb:Oct4
|
| gptkbp:bfsLayer |
5
|