TGF-beta signaling pathway

URI: https://gptkb.org/entity/TGF-beta_signaling_pathway
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf biological pathway
gptkbp:activatedBy gptkb:SMAD2/3
gptkbp:associatedWith gptkb:cancer
developmental disorders
fibrosis
gptkbp:canBeDysregulatedIn gptkb:disease
gptkbp:discoveredIn 1980s
gptkbp:formsComplexWith gptkb:SMAD4
gptkbp:foundIn animals
humans
mammals
gptkbp:GO_term GO:0007179
gptkbp:hasComponent gptkb:SMAD2
gptkb:SMAD3
gptkb:TGFBR2
gptkb:SMAD7
gptkb:TGF-beta1
gptkb:TGF-beta2
gptkb:TGF-beta3
gptkb:TGFBR1
gptkb:SMAD4
gptkbp:hasDownstreamEffect gene expression regulation
gptkbp:hasRole embryonic development
wound healing
immune regulation
tissue homeostasis
https://www.w3.org/2000/01/rdf-schema#label TGF-beta signaling pathway
gptkbp:inhibitedBy gptkb:SMAD7
gptkbp:involves gptkb:SMAD_proteins
TGF-beta ligands
TGF-beta receptors
gptkbp:KEGGID gptkb:hsa04350
gptkbp:modulatedBy phosphorylation
sumoylation
ubiquitination
gptkbp:namedAfter gptkb:Transforming_Growth_Factor_beta
gptkbp:Reactome R-HSA-170834
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
immune response
extracellular matrix production
gptkbp:target therapeutic drugs
gptkbp:bfsParent gptkb:ACVRL1
gptkb:SMAD4
gptkbp:bfsLayer 6