TGF-beta signaling pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:biological_pathway
gptkbp:activatedBy	gptkb:SMAD2/3
gptkbp:associatedWith	gptkb:cancer developmental disorders fibrosis
gptkbp:canBeDysregulatedIn	gptkb:disease
gptkbp:discoveredIn	1980s
gptkbp:formsComplexWith	gptkb:SMAD4
gptkbp:foundIn	animals humans mammals
gptkbp:GO_term	GO:0007179
gptkbp:hasComponent	gptkb:SMAD2 gptkb:SMAD3 gptkb:TGFBR2 gptkb:SMAD7 gptkb:TGF-beta1 gptkb:TGF-beta2 gptkb:TGF-beta3 gptkb:TGFBR1 gptkb:SMAD4
gptkbp:hasDownstreamEffect	gene expression regulation
gptkbp:hasRole	embryonic development wound healing immune regulation tissue homeostasis
gptkbp:inhibitedBy	gptkb:SMAD7
gptkbp:involves	gptkb:SMAD_proteins TGF-beta ligands TGF-beta receptors
gptkbp:KEGGID	gptkb:hsa04350
gptkbp:modulatedBy	phosphorylation sumoylation ubiquitination
gptkbp:namedAfter	gptkb:Transforming_Growth_Factor_beta
gptkbp:Reactome	R-HSA-170834
gptkbp:regulates	gptkb:immune_response apoptosis cell differentiation cell proliferation extracellular matrix production
gptkbp:target	therapeutic drugs
gptkbp:bfsParent	gptkb:ACVRL1 gptkb:SMAD4
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	TGF-beta signaling pathway