|
gptkbp:instance_of
|
gptkb:DNA
|
|
gptkbp:antibody_available
|
for research purposes
|
|
gptkbp:application
|
induced pluripotent stem cells (i PSCs)
|
|
gptkbp:associated_with
|
gptkb:Cell
epigenetic regulation
reprogramming factors
|
|
gptkbp:biomarker_potential
|
for stem cell identification
|
|
gptkbp:breeding_range
|
chromosome 6
|
|
gptkbp:cell_line_studies
|
in cancer research
|
|
gptkbp:cell_type_specificity
|
embryonic stem cells
|
|
gptkbp:challenges
|
developmental defects
|
|
gptkbp:clinical_trial
|
cancer research
in regenerative medicine
|
|
gptkbp:collaborations
|
international research teams
|
|
gptkbp:discovery_year
|
gptkb:1988
|
|
gptkbp:ecological_role
|
transcriptional activator
|
|
gptkbp:expression_assay
|
RT-PCR
|
|
gptkbp:expression_in
|
germ cells
|
|
gptkbp:expression_in_cancer
|
associated with poor prognosis
|
|
gptkbp:expression_in_tissues
|
embryonic tissues
|
|
gptkbp:field_of_study
|
stem cell biology
|
|
gptkbp:function
|
regulates pluripotency
|
|
gptkbp:functional_domains
|
transactivation domain
|
|
gptkbp:funding
|
NIH grants
|
|
gptkbp:gene_expression_analysis
|
in various cancers
|
|
gptkbp:gene_regulation_mechanism
|
binding to DNA sequences
|
|
gptkbp:genetic_studies
|
loss of pluripotency
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OCT4
|
|
gptkbp:initiated_by
|
small molecules
differentiation of stem cells
|
|
gptkbp:interacts_with
|
gptkb:NANOG
gptkb:SOX2
|
|
gptkbp:invention
|
related to stem cell technology
|
|
gptkbp:involved_in
|
cell fate determination
|
|
gptkbp:involvement
|
cellular reprogramming.
|
|
gptkbp:is_expressed_in
|
high in embryonic stem cells
|
|
gptkbp:knockout_effects
|
loss of stem cell characteristics
|
|
gptkbp:location
|
gptkb:Atom
|
|
gptkbp:nutritional_value
|
POU domain
POU family
with transcription co-factors
|
|
gptkbp:orthologs
|
POU5 F1 in other species
|
|
gptkbp:overexpression_effects
|
tumorigenesis
|
|
gptkbp:promoter
|
gptkb:POU5_F1
|
|
gptkbp:promotes
|
self-renewal of stem cells
|
|
gptkbp:protein_type
|
nuclear protein
|
|
gptkbp:publication
|
numerous peer-reviewed articles
|
|
gptkbp:regulatory_compliance
|
post-translational modifications
|
|
gptkbp:regulatory_element
|
enhancer regions
|
|
gptkbp:research
|
CRISPR gene editing
|
|
gptkbp:role
|
gptkb:embryonic_development
|
|
gptkbp:species
|
gptkb:Human
|
|
gptkbp:target_genes
|
genes involved in self-renewal
|
|
gptkbp:transcriptional_targets
|
genes for pluripotency
|
|
gptkbp:weight
|
approximately 45 k Da
|
|
gptkbp:bfsParent
|
gptkb:SOX2
|
|
gptkbp:bfsLayer
|
6
|