|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:POU5F1
|
|
gptkbp:associatedWith
|
induced pluripotent stem cells
cellular reprogramming
|
|
gptkbp:biologicalProcess
|
cell fate determination
stem cell maintenance
tumorigenesis
DNA binding
transcriptional regulation
early embryonic development
reprogramming somatic cells
blastocyst formation
germ layer formation
|
|
gptkbp:discoveredBy
|
gptkb:Hans_R._Schöler
|
|
gptkbp:encodedBy
|
gptkb:POU5F1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000204531
5460
|
|
gptkbp:expressedIn
|
gptkb:germ_cells
embryonic stem cells
|
|
gptkbp:function
|
transcription factor
maintenance of stem cell self-renewal
regulation of pluripotency
|
|
gptkbp:gene
|
gptkb:POU5F1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OCT4
|
|
gptkbp:interactsWith
|
gptkb:NANOG
gptkb:KLF4
gptkb:ESRRB
gptkb:SOX2
gptkb:c-MYC
SALL4
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:memberOf
|
gptkb:POU_family
gptkb:class_V_POU_domain_proteins
|
|
gptkbp:mutationAssociatedWith
|
testicular cancer
infertility
germ cell tumors
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_002701
|
|
gptkbp:regulates
|
gptkb:NANOG
gptkb:SOX2
gptkb:TERT
gptkb:FGF4
regulated by microRNAs
autoregulation
regulated by SOX2
regulated by methylation
UTF1
regulated by NANOG
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains POU domain
contains homeobox domain
|
|
gptkbp:UniProtID
|
gptkb:Q01860
|
|
gptkbp:usedIn
|
gptkb:Yamanaka_factors
|
|
gptkbp:bfsParent
|
gptkb:NANOG
gptkb:miR-145
gptkb:human_induced_pluripotent_stem_cells
gptkb:SOX2
gptkb:AP-2
gptkb:Kruppel-like_factor_4
gptkb:Nanog
gptkb:POU5F1
gptkb:POU5F1_gene
gptkb:SRY-box_transcription_factor_2
gptkb:class_V_POU_domain_proteins
gptkb:primordial_germ_cells
|
|
gptkbp:bfsLayer
|
7
|