Hedgehog signaling pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:biological_pathway
gptkbp:activatedBy	gptkb:Hedgehog_ligands
gptkbp:conservedIn	invertebrates vertebrates
gptkbp:dysregulationAssociatedWith	gptkb:cancer gptkb:medulloblastoma birth defects basal cell carcinoma
gptkbp:firstDescribed	gptkb:Drosophila_melanogaster
gptkbp:foundIn	animals
gptkbp:GO_term	GO:0007224
gptkbp:hasComponent	gptkb:GLI_transcription_factors gptkb:Hedgehog_protein gptkb:Patched_receptor gptkb:Smoothened_receptor gptkb:Suppressor_of_Fused_(SUFU)
gptkbp:includesLigand	gptkb:Indian_hedgehog gptkb:Desert_hedgehog gptkb:Sonic_hedgehog
gptkbp:inhibitedBy	gptkb:sonidegib gptkb:vismodegib gptkb:cyclopamine gptkb:Patched_(PTCH)
gptkbp:involvedIn	organogenesis left-right asymmetry hair follicle development limb development neural tube patterning
gptkbp:modulatedBy	gptkb:primary_cilium gene expression
gptkbp:mutationAssociatedWith	gptkb:Gorlin_syndrome gptkb:holoprosencephaly polydactyly
gptkbp:namedAfter	gptkb:Hedgehog_gene
gptkbp:recipient	gptkb:Smoothened_(SMO) gptkb:Patched_(PTCH)
gptkbp:regulates	gptkb:GLI_family cell differentiation cell proliferation embryonic development stem cell maintenance tissue patterning
gptkbp:relatedTo	gptkb:BMP_signaling_pathway gptkb:Notch_signaling_pathway gptkb:Wnt_signaling_pathway
gptkbp:targetGene	gptkb:PTCH1 gptkb:GLI1 gptkb:HHIP
gptkbp:bfsParent	gptkb:SOX2 gptkb:Signal_transduction gptkb:SHH
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Hedgehog signaling pathway