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Hedgehog signaling pathway
URI:
https://gptkb.org/entity/Hedgehog_signaling_pathway
GPTKB entity
Statements (51)
Predicate
Object
gptkbp:instanceOf
biological pathway
gptkbp:activatedBy
gptkb:Hedgehog_ligands
gptkbp:conservedIn
invertebrates
vertebrates
gptkbp:dysregulationAssociatedWith
gptkb:cancer
gptkb:medulloblastoma
birth defects
basal cell carcinoma
gptkbp:firstDescribed
gptkb:Drosophila_melanogaster
gptkbp:foundIn
animals
gptkbp:GO_term
GO:0007224
gptkbp:hasComponent
gptkb:GLI_transcription_factors
gptkb:Hedgehog_protein
gptkb:Patched_receptor
gptkb:Smoothened_receptor
gptkb:Suppressor_of_Fused_(SUFU)
https://www.w3.org/2000/01/rdf-schema#label
Hedgehog signaling pathway
gptkbp:includesLigand
gptkb:Indian_hedgehog
gptkb:Desert_hedgehog
gptkb:Sonic_hedgehog
gptkbp:inhibitedBy
gptkb:sonidegib
gptkb:vismodegib
gptkb:cyclopamine
gptkb:Patched_(PTCH)
gptkbp:involvedIn
organogenesis
left-right asymmetry
hair follicle development
limb development
neural tube patterning
gptkbp:modulatedBy
gptkb:primary_cilium
gene expression
gptkbp:mutationAssociatedWith
gptkb:Gorlin_syndrome
gptkb:holoprosencephaly
polydactyly
gptkbp:namedAfter
gptkb:Hedgehog_gene
gptkbp:recipient
gptkb:Smoothened_(SMO)
gptkb:Patched_(PTCH)
gptkbp:regulates
gptkb:GLI_family
cell differentiation
cell proliferation
embryonic development
stem cell maintenance
tissue patterning
gptkbp:relatedTo
gptkb:BMP_signaling_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
gptkbp:targetGene
gptkb:PTCH1
gptkb:GLI1
gptkb:HHIP
gptkbp:bfsParent
gptkb:Class_F_(Frizzled/Taste2)
gptkbp:bfsLayer
6