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gptkbp:instanceOf
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gptkb:biological_pathway
|
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gptkbp:activatedBy
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gptkb:PLCĪ³_pathway
gptkb:STAT_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
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gptkbp:database
|
KEGG: hsa04010
Reactome: R-HSA-190236
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gptkbp:dysregulationAssociatedWith
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gptkb:cancer
developmental disorders
skeletal disorders
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gptkbp:firstDescribed
|
1980s
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gptkbp:foundIn
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animals
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gptkbp:hasRole
|
wound healing
neurogenesis
organogenesis
skeletal development
vascular development
tissue repair
limb development
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gptkbp:involves
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FGF receptors (FGFRs)
fibroblast growth factors (FGFs)
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gptkbp:ligand
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gptkb:FGF1
gptkb:FGF2
gptkb:FGF8
gptkb:FGF3
gptkb:FGF4
|
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gptkbp:modulatedBy
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gptkb:DUSP6
SEF (similar expression to FGF genes)
sprouty proteins
|
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gptkbp:mutationAssociatedWith
|
FGFR1 causes Kallmann syndrome
FGFR2 causes craniosynostosis syndromes
FGFR3 causes achondroplasia
|
|
gptkbp:recipient
|
gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
gptkb:FGFR2
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
embryonic development
angiogenesis
cell migration
|
|
gptkbp:requires
|
gptkb:heparan_sulfate_proteoglycans
|
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gptkbp:target
|
FGFR inhibitors
anti-FGF antibodies
|
|
gptkbp:bfsParent
|
gptkb:MAPK3
gptkb:Sprouty4
gptkb:FGFR3
gptkb:SOX2
gptkb:FGF4
|
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gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGF signaling pathway
|