Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:PLCĪ³_pathway
gptkb:STAT_pathway gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway |
| gptkbp:database |
KEGG: hsa04010
Reactome: R-HSA-190236 |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
developmental disorders skeletal disorders |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
animals
|
| gptkbp:hasRole |
wound healing
neurogenesis organogenesis skeletal development vascular development tissue repair limb development |
| https://www.w3.org/2000/01/rdf-schema#label |
FGF signaling pathway
|
| gptkbp:involves |
FGF receptors (FGFRs)
fibroblast growth factors (FGFs) |
| gptkbp:ligand |
gptkb:FGF1
gptkb:FGF2 gptkb:FGF8 gptkb:FGF3 gptkb:FGF4 |
| gptkbp:modulatedBy |
gptkb:DUSP6
SEF (similar expression to FGF genes) sprouty proteins |
| gptkbp:mutationAssociatedWith |
FGFR1 causes Kallmann syndrome
FGFR2 causes craniosynostosis syndromes FGFR3 causes achondroplasia |
| gptkbp:recipient |
gptkb:FGFR3
gptkb:FGFR1 gptkb:FGFR4 gptkb:FGFR2 |
| gptkbp:regulates |
cell differentiation
cell proliferation embryonic development angiogenesis cell migration |
| gptkbp:requires |
gptkb:heparan_sulfate_proteoglycans
|
| gptkbp:target |
FGFR inhibitors
anti-FGF antibodies |
| gptkbp:bfsParent |
gptkb:FGFR3
gptkb:FGFR2 |
| gptkbp:bfsLayer |
6
|