Statements (161)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:application |
gptkb:Cell
regenerative medicine tissue engineering therapeutic cloning |
| gptkbp:associated_with |
gptkb:Cell
cancer stem cells |
| gptkbp:breeding_behavior |
other species
|
| gptkbp:breeding_range |
17p13.1
|
| gptkbp:challenges |
loss of pluripotency
|
| gptkbp:code |
chromosome 12
|
| gptkbp:discovered_by |
gptkb:James_Thomson
|
| gptkbp:discovery_year |
gptkb:2003
|
| gptkbp:downregulated_in |
differentiated cells
|
| gptkbp:function |
regulates pluripotency
regulation of pluripotency |
| gptkbp:genetic_studies |
developmental disorders
linked to developmental disorders |
| gptkbp:has_role |
self-renewal
early embryonic development |
| https://www.w3.org/2000/01/rdf-schema#label |
NANOG
|
| gptkbp:influences |
cell differentiation
gene expression |
| gptkbp:initiated_by |
differentiation
|
| gptkbp:interacts_with |
gptkb:OCT4
gptkb:SOX2 |
| gptkbp:involved_in |
gptkb:developers
embryogenesis stem cell maintenance cell fate determination |
| gptkbp:is_associated_with |
cell cycle regulation
developmental biology reproductive biology pluripotent stem cells cellular identity stem cell niche biological research. germline development reprogramming pluripotent stem cell lines pluripotent state |
| gptkbp:is_downregulated_in |
differentiated cells
|
| gptkbp:is_essential_for |
gptkb:embryonic_development
stem cell maintenance |
| gptkbp:is_expressed_in |
gptkb:ovaries
testis placenta adult stem cells intestinal stem cells induced pluripotent stem cells somatic cells germ cells embryonic stem cells neural stem cells pluripotent stem cells muscle stem cells cancerous tissues early embryogenesis early embryos early embryonic development embryonic germ cells high in pluripotent cells low in differentiated cells adipose stem cells corneal stem cells dental pulp stem cells early gastrulation fertilized oocytes hair follicle stem cells inner cell mass pluripotent cell lines pluripotent progenitors salivary gland stem cells skin stem cells stem cell niches |
| gptkbp:is_found_in |
mice
|
| gptkbp:is_involved_in |
cell cycle regulation
cellular homeostasis cellular metabolism immune response muscle regeneration tumorigenesis cellular aging cellular differentiation genetic stability tissue regeneration neurogenesis organogenesis cellular communication cellular signaling cellular reprogramming tissue homeostasis cell fate determination neural differentiation embryo implantation reprogramming of somatic cells cellular repair bone regeneration cell fate decisions neural repair cardiac regeneration embryonic stem cell differentiation cellular plasticity cartilage regeneration embryonic axis formation liver regeneration pancreatic regeneration retinal regeneration |
| gptkbp:is_linked_to |
aging
disease progression tumorigenesis cellular aging infertility epigenetic modifications metastasis therapeutic applications epigenetic regulation cancer stem cells cellular plasticity |
| gptkbp:is_part_of |
cellular networks
stem cell maintenance stem cell niche gene regulatory networks pluripotency network stem cell signaling pathways |
| gptkbp:is_regulated_by |
transcription factors
epigenetic modifications signaling pathways extracellular signals external signals transcriptional repressors micro RNAs |
| gptkbp:is_studied_for |
biomedical applications
gene editing technologies therapeutic potential |
| gptkbp:is_studied_in |
cancer research
cancer biology stem cell research |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
cancer therapies |
| gptkbp:is_upregulated_in |
germ cell tumors
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:orthologs |
other species
NANOG in humans NANOG in mice |
| gptkbp:part_of |
pluripotency network
|
| gptkbp:promoter |
gptkb:NANOG
|
| gptkbp:promoter_region |
contains OCT4 binding sites
|
| gptkbp:protein_type |
gptkb:DNA
|
| gptkbp:regulates |
self-renewal
|
| gptkbp:requires |
germline development
|
| gptkbp:role |
tumorigenesis
cancer progression |
| gptkbp:targets |
gptkb:RNA_Polymerase
transcription factors micro RNAs |
| gptkbp:transcriptional_targets |
various genes
|
| gptkbp:upregulated_in |
certain cancers
|
| gptkbp:bfsParent |
gptkb:POU5_F1
gptkb:SOX2 |
| gptkbp:bfsLayer |
6
|