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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:OCT4
gptkb:POU_domain,_class_5,_transcription_factor_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
stem cell biology
|
|
gptkbp:discoveredBy
|
gptkb:Hans_R._Schöler
|
|
gptkbp:domain
|
gptkb:POU-specific_domain
homeobox domain
|
|
gptkbp:encodes
|
gptkb:octamer-binding_transcription_factor_4
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000204531
5460
|
|
gptkbp:expressedIn
|
gptkb:germ_cells
embryonic stem cells
|
|
gptkbp:firstDescribed
|
1990
|
|
gptkbp:function
|
transcription factor
regulation of pluripotency
maintenance of self-renewal in embryonic stem cells
|
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gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9221
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
POU5F1
|
|
gptkbp:importantFor
|
cell fate determination
early embryonic development
maintenance of undifferentiated state
|
|
gptkbp:interactsWith
|
gptkb:NANOG
gptkb:KLF4
gptkb:SOX2
gptkb:c-MYC
|
|
gptkbp:length
|
360 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
6p21.33
|
|
gptkbp:molecularWeight
|
38 kDa
|
|
gptkbp:mutationAssociatedWith
|
infertility
germ cell tumors
|
|
gptkbp:OMIM
|
164177
|
|
gptkbp:orthologInMouse
|
Pou5f1
|
|
gptkbp:regulates
|
gptkb:NANOG
gptkb:SOX2
gptkb:POU_family
regulated by microRNAs
autoregulation
genes involved in pluripotency
regulated by DNA methylation
regulated by histone modification
|
|
gptkbp:regulatoryElement
|
promoter
enhancer
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
gptkb:Q01860
|
|
gptkbp:usedIn
|
gptkb:induced_pluripotent_stem_cell_(iPSC)_reprogramming
|
|
gptkbp:bfsParent
|
gptkb:Oct3/4
|
|
gptkbp:bfsLayer
|
6
|