SRY-box transcription factor 2

URI: https://gptkb.org/entity/SRY-box_transcription_factor_2
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alsoKnownAs gptkb:SOX2
gptkbp:associatedWith gptkb:cancer
anophthalmia
microphthalmia
gptkbp:biologicalProcess DNA binding
transcription factor activity
gptkbp:discoveredBy gptkb:Yoshiki_Sasai
gptkbp:discoveredIn 1994
gptkbp:domain HMG-box domain
gptkbp:encodedBy gptkb:SOX2_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000181449
6657
gptkbp:expressedIn embryonic stem cells
neural stem cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcriptional regulation
maintenance of pluripotency
regulation of embryonic development
gptkbp:gene gptkb:SOX2
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 11195
https://www.w3.org/2000/01/rdf-schema#label SRY-box transcription factor 2
gptkbp:interactsWith gptkb:NANOG
gptkb:KLF4
gptkb:OCT4
gptkb:c-MYC
gptkbp:length 317 amino acids
gptkbp:locatedOnChromosome 3q26.3-q27
gptkbp:memberOf gptkb:SOX_family
gptkbp:molecularWeight 34 kDa
gptkbp:mutationAssociatedWith developmental disorders
ocular malformations
gptkbp:OMIM 184429
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkbp:regulates gptkb:NANOG
gptkb:OCT4
gptkb:FGF4
differentiation
self-renewal
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID gptkb:P48431
gptkbp:usedIn induced pluripotent stem cell generation
gptkbp:bfsParent gptkb:Sox2
gptkbp:bfsLayer 6