SRY-box transcription factor 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:transcription_factor gptkb:protein
gptkbp:alsoKnownAs	gptkb:SOX2
gptkbp:associatedWith	gptkb:cancer anophthalmia microphthalmia
gptkbp:biologicalProcess	DNA binding transcription factor activity
gptkbp:discoveredBy	gptkb:Yoshiki_Sasai
gptkbp:discoveredIn	1994
gptkbp:domain	HMG-box domain
gptkbp:encodedBy	gptkb:SOX2_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000181449 6657
gptkbp:expressedIn	embryonic stem cells neural stem cells
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	transcriptional regulation maintenance of pluripotency regulation of embryonic development
gptkbp:gene	gptkb:SOX2
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	11195
gptkbp:interactsWith	gptkb:NANOG gptkb:KLF4 gptkb:OCT4 gptkb:c-MYC
gptkbp:length	317 amino acids
gptkbp:locatedOnChromosome	3q26.3-q27
gptkbp:memberOf	gptkb:SOX_family
gptkbp:molecularWeight	34 kDa
gptkbp:mutationAssociatedWith	developmental disorders ocular malformations
gptkbp:OMIM	184429
gptkbp:orthologIn	gptkb:Danio_rerio gptkb:Gallus_gallus gptkb:Mus_musculus
gptkbp:regulates	gptkb:NANOG gptkb:OCT4 gptkb:FGF4 differentiation self-renewal
gptkbp:subcellularLocation	gptkb:nucleus
gptkbp:UniProtID	gptkb:P48431
gptkbp:usedIn	induced pluripotent stem cell generation
gptkbp:bfsParent	gptkb:Sox2
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	SRY-box transcription factor 2