|
gptkbp:instanceOf
|
gptkb:cancer
gptkb:disease
|
|
gptkbp:affects
|
eye
retina
|
|
gptkbp:canBeBilateral
|
true
|
|
gptkbp:canBeUnilateral
|
true
|
|
gptkbp:canMetastasizeTo
|
brain
lymph nodes
bone marrow
|
|
gptkbp:cause
|
blindness
death if untreated
|
|
gptkbp:causedBy
|
RB1 gene mutation
|
|
gptkbp:commonIn
|
children
|
|
gptkbp:diagnosedBy
|
MRI
genetic testing
ultrasound
ophthalmic examination
|
|
gptkbp:firstDescribed
|
gptkb:Wilhelm_Karl_Ernst_Busch
1809
|
|
gptkbp:hasScreening
|
genetic counseling
red reflex test
|
|
gptkbp:hasType
|
hereditary retinoblastoma
sporadic retinoblastoma
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
retinoblastoma
|
|
gptkbp:ICD-10_code
|
C69.2
|
|
gptkbp:isPediatricCancer
|
true
|
|
gptkbp:MeSH_ID
|
D012177
|
|
gptkbp:OMIM
|
180200
|
|
gptkbp:originatedIn
|
retinal cell
|
|
gptkbp:prevalence
|
1 in 15,000 to 20,000 live births
|
|
gptkbp:prognosis
|
good if detected early
|
|
gptkbp:rarity
|
true
|
|
gptkbp:riskFactor
|
family history
germline RB1 mutation
|
|
gptkbp:stageName
|
gptkb:International_Intraocular_Retinoblastoma_Classification
gptkb:Reese-Ellsworth_classification
|
|
gptkbp:symptom
|
gptkb:leukocoria
vision loss
strabismus
eye redness
eye swelling
|
|
gptkbp:treatment
|
radiation therapy
chemotherapy
laser therapy
cryotherapy
enucleation
|
|
gptkbp:bfsParent
|
gptkb:RB1
|
|
gptkbp:bfsLayer
|
6
|