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gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
transcription factors
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:CADASIL
gptkb:Alagille_syndrome
gptkb:T-cell_acute_lymphoblastic_leukemia
|
|
gptkbp:conservedIn
|
gptkb:metazoans
|
|
gptkbp:containsGene
|
gptkb:NOTCH3
gptkb:NOTCH1
gptkb:NOTCH2
gptkb:NOTCH4
|
|
gptkbp:describedBy
|
gptkb:Reactome_database
gptkb:KEGG_pathway_database
|
|
gptkbp:discoveredBy
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:foundIn
|
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
animals
humans
|
|
gptkbp:has_ligand_gene
|
gptkb:DLL1
gptkb:DLL3
gptkb:DLL4
gptkb:JAG1
gptkb:JAG2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Notch signaling pathway
|
|
gptkbp:involves
|
gptkb:CSL_transcription_factor
gptkb:Delta_ligand
gptkb:Jagged_ligand
gptkb:Mastermind-like_protein
gptkb:NICD_(Notch_intracellular_domain)
gptkb:Notch_receptor
gptkb:gamma-secretase
endocytosis
ubiquitination
proteolytic cleavage
|
|
gptkbp:mediatedBy
|
cell-cell contact
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
angiogenesis
cell fate determination
neurogenesis
stem cell maintenance
organ development
hematopoiesis
immune system development
|
|
gptkbp:requires
|
embryonic development
tissue homeostasis
|
|
gptkbp:target
|
therapeutic antibodies
gamma-secretase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:Notch_gene
gptkb:Mib_(gene)
gptkb:Ralf_Adams
|
|
gptkbp:bfsLayer
|
6
|