Mitogen-activated protein kinase 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:MEK1 gptkb:MEK2
gptkbp:alsoKnownAs	gptkb:ERK2 gptkb:p42MAPK
gptkbp:associatedWith	gptkb:cardiofaciocutaneous_syndrome gptkb:cancer gptkb:Noonan_syndrome
gptkbp:EC_number	2.7.11.24
gptkbp:encodedBy	gptkb:MAPK1_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000100030 GC22M030282
gptkbp:function	differentiation signal transduction cell cycle progression cell proliferation regulation transcription regulation
gptkbp:gene	gptkb:MAPK1
gptkbp:HGNC_ID	6871
https://www.w3.org/2000/01/rdf-schema#label	Mitogen-activated protein kinase 1
gptkbp:inhibitedBy	gptkb:PD98059 gptkb:U0126
gptkbp:interactsWith	gptkb:MAP2K1 gptkb:MAP2K2 gptkb:PTPN7 gptkb:DUSP6 gptkb:BRAF gptkb:GRB2 gptkb:RAF1 gptkb:SOS1 gptkb:KSR1
gptkbp:locatedOnChromosome	22q11.22
gptkbp:molecularWeight	41 kDa
gptkbp:OMIM	176948
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:part_of_pathway	gptkb:MAPK/ERK_pathway
gptkbp:PDB	gptkb:2ERK
gptkbp:phosphorylates	gptkb:ELK1 gptkb:MNK1 gptkb:MSK1 gptkb:RSK gptkb:c-Myc gptkb:c-Fos
gptkbp:RefSeq	NP_002736.3
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:P28482
gptkbp:bfsParent	gptkb:ERK2 gptkb:MAPK1 gptkb:MAPK1_gene
gptkbp:bfsLayer	7