|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Proto-oncogene_c-Fos
gptkb:AP-1_transcription_factor_subunit_c-Fos
Finkel-Biskis-Jinkins murine osteogenic sarcoma virus oncogene homolog
|
|
gptkbp:associatedWith
|
immediate early gene response
|
|
gptkbp:binds
|
gptkb:gene
AP-1 site
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:FOS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000170345
2353
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
Curran and Morgan
|
|
gptkbp:formsAP-1TranscriptionFactor
|
gptkb:AP-1
|
|
gptkbp:formsComplexWith
|
gptkb:c-Jun
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
HGNC:3796
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Fos
|
|
gptkbp:inducedBy
|
stress
cytokines
growth factors
UV radiation
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
14q24.3
|
|
gptkbp:marking
|
neuronal activation
|
|
gptkbp:memberOf
|
gptkb:Fos_family
|
|
gptkbp:OMIM
|
164810
|
|
gptkbp:orthologInMouse
|
gptkb:Fos
|
|
gptkbp:PDB
|
1FOS
|
|
gptkbp:phosphorylates
|
gptkb:MAPK
gptkb:ERK
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
immune response
neuronal activity
target genes
|
|
gptkbp:relatedTo
|
gptkb:cancer
oncogenesis
|
|
gptkbp:structure
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:UniProtID
|
P01100
|
|
gptkbp:usedIn
|
cancer research
neuroscience research
cell signaling studies
|
|
gptkbp:bfsParent
|
gptkb:ERK1
gptkb:ERK1/2
gptkb:ERK2
gptkb:MAPK1
gptkb:p42_MAPK
gptkb:p44_MAPK
gptkb:ELK1
gptkb:JNK_proteins
gptkb:c-Jun
gptkb:ERK5_pathway
gptkb:AP1
|
|
gptkbp:bfsLayer
|
7
|