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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
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gptkb:ERK2
gptkb:Extracellular_signal-regulated_kinase_2
gptkb:MAP_kinase_2
p42-MAPK
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gptkbp:database
|
gptkb:Reactome:_R-HSA-5673001
Ensembl: ENSG00000100030
GeneID: 5594
HGNC: 6871
KEGG: hsa:5594
OMIM: 176948
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gptkbp:disease_involvement
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gptkb:cancer
gptkb:Noonan_syndrome
cardiomyopathy
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gptkbp:encodedBy
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gptkb:MAPK1
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gptkbp:enzymeClassification
|
gptkb:EC_2.7.11.24
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gptkbp:function
|
involved in the MAPK/ERK signaling pathway
regulates cell proliferation, differentiation, and survival
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gptkbp:hasIsoform
|
MAPK1 isoform 1
MAPK1 isoform 2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P28482
|
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gptkbp:interactsWith
|
gptkb:MAP2K1
gptkb:MEK1
gptkb:MEK2
gptkb:ELK1
gptkb:MAP2K2
gptkb:DUSP6
gptkb:GRB2
gptkb:RAF1
gptkb:SOS1
gptkb:RSK1
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|
gptkbp:length
|
360 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_22q11.22
|
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gptkbp:molecularWeight
|
41.4 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:EGF_signaling_pathway
insulin signaling pathway
|
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gptkbp:PDB
|
gptkb:2ERK
1TVO
4QTB
5K4I
|
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gptkbp:phosphorylates
|
Thr185
Tyr187
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:protein_name
|
gptkb:Mitogen-activated_protein_kinase_1
|
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gptkbp:reviewedBy
|
yes
|
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gptkbp:sequenceStatus
|
complete
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
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gptkbp:bfsParent
|
gptkb:ERK1/2
gptkb:ERK2
gptkb:Extracellular_signal-regulated_kinase
gptkb:MAPK1
gptkb:MAPK1_gene
gptkb:p42_MAPK
gptkb:p44_MAPK
|
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gptkbp:bfsLayer
|
7
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