|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
phosphorylation by MEK1/2
|
|
gptkbp:alias
|
gptkb:MAP_kinase_2
gptkb:Mitogen-activated_protein_kinase_1
gptkb:p42MAPK
|
|
gptkbp:discoveredBy
|
Meloche S et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100030
5594
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.11.24
|
|
gptkbp:fullName
|
gptkb:Extracellular_signal-regulated_kinase_2
|
|
gptkbp:function
|
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MAPK1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6871
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK2
|
|
gptkbp:inhibitedBy
|
phosphatases
|
|
gptkbp:interactsWith
|
gptkb:MEK1
gptkb:MEK2
gptkb:ELK1
gptkb:c-Myc
gptkb:DUSP6
gptkb:Sprouty_proteins
gptkb:RSK1
gptkb:c-Fos
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_22q11.22
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
41 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:ERK1
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:PDB
|
gptkb:2ERK
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
other kinases
Thr185
Tyr187
|
|
gptkbp:RefSeq
|
gptkb:NP_002736.2
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
gene expression
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:MEK1
gptkb:MEK2
gptkb:extracellular_signal-regulated_kinase
gptkb:mitogen-activated_protein_kinase
|
|
gptkbp:bfsLayer
|
6
|