|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ERK2
gptkb:EIP38
gptkb:ERK-2
gptkb:MAP_kinase_2
gptkb:PRKM1
gptkb:p41mapk
gptkb:p42-ERK
|
|
gptkbp:alternativeName
|
gptkb:ERK2
gptkb:MAPK2
gptkb:PRKM1
gptkb:p42MAPK
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100030
5594
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
cell proliferation
development
differentiation
signal transduction
transcription regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6871
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:locatedOnChromosome
|
chromosome 22
22q11.22
|
|
gptkbp:OMIM
|
176948
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk1
|
|
gptkbp:orthologInZebrafish
|
mapk1
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
gptkb:EGFR_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:proteinFamily
|
gptkb:MAP_kinase_family
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
gene expression
cell migration
cell cycle
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:ERK
gptkb:RTK-RAS_pathway
|
|
gptkbp:bfsLayer
|
6
|