|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK2
gptkb:MAPK1
|
|
gptkbp:decommissioned
|
phosphatases
|
|
gptkbp:discoveredBy
|
Meloche S et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:MAPK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5594
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.24
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
signal transduction
regulation of cell proliferation
regulation of transcription
regulation of differentiation
|
|
gptkbp:gene
|
gptkb:MAPK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p42MAPK
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
gptkb:FR180204
|
|
gptkbp:locatedOnChromosome
|
22q11.22
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:phosphorylates
|
gptkb:CREB
gptkb:ELK1
gptkb:MNK1
gptkb:RSK
gptkb:c-Myc
gptkb:STAT3
gptkb:c-Fos
gptkb:p90RSK
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell migration
cell cycle
|
|
gptkbp:significance
|
implicated in cancer
implicated in developmental disorders
|
|
gptkbp:structure
|
serine/threonine kinase
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:ERK2
gptkb:MAPK1
gptkb:MAPK1_gene
|
|
gptkbp:bfsLayer
|
7
|