|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:ERK1/2
phosphorylation
|
|
gptkbp:alternativeName
|
gptkb:p90RSK
RPS6KA1 protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
cell proliferation
cell survival
cell growth
|
|
gptkbp:discoveredBy
|
Erikson & Maller
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:domain
|
kinase domain
AGC kinase domain
CTKD (C-terminal kinase domain)
NTKD (N-terminal kinase domain)
|
|
gptkbp:encodedBy
|
RPS6KA1 gene
|
|
gptkbp:fullName
|
Ribosomal S6 kinase 1
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
gptkbp:gene
|
RPS6KA1
|
|
gptkbp:hasIsoform
|
RSK2
RSK3
RSK4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RSK1
|
|
gptkbp:inhibitedBy
|
BI-D1870
SL0101
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.11
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:AGC_protein_kinase_family
RSK family
|
|
gptkbp:molecularWeight
|
90 kDa
|
|
gptkbp:OMIM
|
602134
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2Z7Q
3G51
|
|
gptkbp:phosphorylates
|
gptkb:CREB
gptkb:BAD
gptkb:GSK3
gptkb:c-Fos
NFAT3
|
|
gptkbp:RefSeq
|
NP_002944.2
|
|
gptkbp:regulates
|
apoptosis
gene expression
cell cycle
|
|
gptkbp:UniProtID
|
Q15418
|
|
gptkbp:bfsParent
|
gptkb:ERK2
gptkb:MAPK1
gptkb:p42_MAPK
gptkb:Tsc2
|
|
gptkbp:bfsLayer
|
7
|