|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK2
gptkb:p42MAPK
MAP kinase 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
gptkb:RASopathies
cardiomyopathy
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell migration
ATP binding
apoptotic process
cellular response to growth factor stimulus
protein serine/threonine kinase activity
cellular response to stress
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
multiple research groups
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100030
5594
|
|
gptkbp:function
|
signal transduction
regulation of cell cycle
regulation of cell proliferation
regulation of transcription
regulation of differentiation
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mapk1
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
gptkb:FR180204
|
|
gptkbp:length
|
360
|
|
gptkbp:locatedOnChromosome
|
22q11.22
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:protein_kinase_superfamily
|
|
gptkbp:molecularWeight
|
41.4 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk1
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:PDB
|
gptkb:2ERK
6OPG
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
other kinases
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:Extracellular_signal-regulated_kinase
gptkb:MAPK1
gptkb:MAPK1_gene
|
|
gptkbp:bfsLayer
|
7
|