|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CEK
gptkb:bFGF-R
gptkb:FLG
gptkb:CD331
HBGFR
|
|
gptkbp:chromosomeArm
|
8p11.23
|
|
gptkbp:discoveredBy
|
gptkb:P._Leder
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:domain
|
protein kinase domain
immunoglobulin-like domain
|
|
gptkbp:encodes
|
gptkb:FGFR1_protein
|
|
gptkbp:Entrez_Gene_ID
|
2260
ENSG00000077782
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
brain
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_1
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:3688
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR1
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:PLCĪ³
gptkb:PTPN11
gptkb:SHC1
gptkb:FGF1
gptkb:FGF18
gptkb:FGF2
gptkb:FGF9
gptkb:SRC
gptkb:GRB2
gptkb:SOS1
gptkb:FGF10
gptkb:FGF17
gptkb:FGF22
gptkb:FGF5
gptkb:FGF6
gptkb:FGF8
gptkb:FRS2
gptkb:STAT3
gptkb:FGF3
gptkb:FGF4
heparan sulfate
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
embryonic development
angiogenesis
|
|
gptkbp:locatedOnChromosome
|
8
|
|
gptkbp:molecularWeight
|
92 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Kallmann_syndrome
gptkb:Pfeiffer_syndrome
gptkb:osteoglophonic_dysplasia
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Fgfr1
|
|
gptkbp:pathway
|
gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:proteinFamily
|
fibroblast growth factor receptor family
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:targetOfDrug
|
gptkb:ponatinib
gptkb:AZD4547
gptkb:dovitinib
gptkb:erdafitinib
gptkb:futibatinib
gptkb:infigratinib
gptkb:rogaratinib
gptkb:pemigatinib
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:UniProtID
|
P11362
|
|
gptkbp:bfsParent
|
gptkb:Lenvima
|
|
gptkbp:bfsLayer
|
5
|