|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:receptor_tyrosine_kinases
growth factor receptors
|
|
gptkbp:discoveredBy
|
gptkb:Kazuo_Ui
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:domain
|
gptkb:PH_domain
SH2 domain
SH3 domain
|
|
gptkbp:enzymeCommissionNumber
|
3.1.4.11
|
|
gptkbp:fullName
|
gptkb:Phospholipase_C_gamma
|
|
gptkbp:function
|
generates second messengers IP3 and DAG
hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2)
|
|
gptkbp:gene
|
gptkb:PLCG1
gptkb:PLCG2
|
|
gptkbp:hasIsoform
|
gptkb:PLCγ1
gptkb:PLCγ2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCγ
|
|
gptkbp:involvedIn
|
cell proliferation
cell signaling
immune response
calcium signaling
|
|
gptkbp:locatedOnChromosome
|
16q23.3 (PLCG2)
20q12-q13.1 (PLCG1)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
autoimmune diseases
immunodeficiency
|
|
gptkbp:phosphorylates
|
tyrosine kinases
|
|
gptkbp:proteinFamily
|
gptkb:phospholipase_C_family
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
multi-domain protein
|
|
gptkbp:UniProtID
|
P16885 (PLCG2)
P19174 (PLCG1)
|
|
gptkbp:bfsParent
|
gptkb:c-Met
gptkb:FGFR1
gptkb:EGFR_signaling_pathway
gptkb:phospholipase_C
gptkb:FGFR2
|
|
gptkbp:bfsLayer
|
6
|