ponatinib

URI: https://gptkb.org/entity/ponatinib

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:drug
gptkbp:administeredBy	oral
gptkbp:approvalYear	2012
gptkbp:approvedBy	gptkb:FDA
gptkbp:ATCCode	L01XE24
gptkbp:brand	Iclusig
gptkbp:CASNumber	943319-70-8
gptkbp:contraindication	pregnancy
gptkbp:developedBy	resistant CML mutations (T315I mutation)
gptkbp:discoveredBy	gptkb:Ariad_Pharmaceuticals
gptkbp:eliminationHalfLife	24 hours
gptkbp:hasMolecularFormula	C29H27F3N6O
https://www.w3.org/2000/01/rdf-schema#label	ponatinib
gptkbp:KEGGID	D09913
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	BCR-ABL inhibitor inhibits VEGFR, FGFR, PDGFR, SRC, KIT, RET
gptkbp:metabolism	liver
gptkbp:molecularWeight	532.6 g/mol
gptkbp:PubChem_CID	gptkb:DB08865 24826799 CHEMBL1078661
gptkbp:sideEffect	fatigue hypertension thrombosis pancreatitis rash
gptkbp:UNII	8LJ08WK8A3
gptkbp:usedFor	gptkb:chronic_myeloid_leukemia gptkb:Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia
gptkbp:bfsParent	gptkb:BCR-ABL gptkb:FGFR1 gptkb:chronic_myeloid_leukemia
gptkbp:bfsLayer	6