gptkbp:instanceOf
|
gptkb:protein
|
gptkbp:alternativeSplicing
|
yes
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Kallmann_syndrome
gptkb:Pfeiffer_syndrome
|
gptkbp:domain
|
immunoglobulin-like domain
tyrosine kinase domain
|
gptkbp:encodedBy
|
gptkb:FGFR1_gene
|
gptkbp:Entrez_Gene_ID
|
2260
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:testis
brain
|
gptkbp:formsComplexWith
|
gptkb:heparan_sulfate_proteoglycans
FGF ligand
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_1
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
gptkbp:HGNC_ID
|
HGNC:3688
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR1 protein
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
embryonic development
angiogenesis
|
gptkbp:locatedOnChromosome
|
8p11.23
|
gptkbp:location
|
gptkb:cell_membrane
|
gptkbp:molecularWeight
|
98 kDa
|
gptkbp:mutationAssociatedWith
|
developmental disorders
oncogenesis
|
gptkbp:orthologIn
|
gptkb:meat
gptkb:mouse
gptkb:zebrafish
|
gptkbp:PDB
|
1FGK
|
gptkbp:phosphorylates
|
tyrosine residues
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
|
gptkbp:signalTransductionPathway
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:PLCγ_pathway
|
gptkbp:target
|
tyrosine kinase inhibitors
|
gptkbp:UniProtID
|
P11362
|
gptkbp:bfsParent
|
gptkb:FGFR1
|
gptkbp:bfsLayer
|
6
|