|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
D8S1147E
FGF-18
fibroblast growth factor 18
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
osteoarthritis
cartilage regeneration
|
|
gptkbp:clinicalTrialPhase
|
sprifermin (recombinant FGF18)
|
|
gptkbp:discoveredBy
|
1998
|
|
gptkbp:encodedBy
|
FGF18 gene
|
|
gptkbp:Entrez_Gene_ID
|
8817
ENSG00000156427
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
heart
liver
collagen
|
|
gptkbp:fullName
|
Fibroblast growth factor 18
|
|
gptkbp:function
|
embryonic development
cell growth
skeletal development
tissue repair
cartilage development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTherapeuticUse
|
osteoarthritis treatment (investigational)
|
|
gptkbp:HGNC_ID
|
3681
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGF18
|
|
gptkbp:length
|
207 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q35.1
|
|
gptkbp:memberOf
|
gptkb:fibroblast_growth_factor_family
|
|
gptkbp:molecularWeight
|
22 kDa
|
|
gptkbp:OMIM
|
603726
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:FGF_signaling_pathway
|
|
gptkbp:PDB
|
2WJY
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:recipient
|
gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
gptkb:FGFR2
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:UniProtID
|
O76093
|
|
gptkbp:bfsParent
|
gptkb:FGFR3
gptkb:FGFR1
|
|
gptkbp:bfsLayer
|
6
|