|
gptkbp:instanceOf
|
gptkb:biological_pathway
|
|
gptkbp:activatedBy
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:component
|
signal transduction
cellular communication
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:inhibitedBy
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:involves
|
gptkb:RAS_proteins
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
gptkb:PI3K
gptkb:RAF_kinase
gptkb:AKT
gptkb:ERK
gptkb:GDP
gptkb:MEK
gptkb:GTP
gptkb:GRB2_adaptor_protein
gptkb:SOS_(guanine_nucleotide_exchange_factor)
GTPase activity
|
|
gptkbp:launched
|
gptkb:receptor_tyrosine_kinases
growth factor receptors
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
uncontrolled cell growth
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:studiedIn
|
oncology
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:BRAF_gene
gptkb:GRB2
gptkb:Neuroblastoma_RAS_viral_oncogene_homolog
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS signaling pathway
|