|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GRB1
gptkb:PI3KR1
gptkb:p85-ALPHA
gptkb:p85A
gptkb:p85alpha
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:agammaglobulinemia
insulin resistance
|
|
gptkbp:biologicalProcess
|
signal transduction
metabolism
cell growth
apoptosis regulation
protein binding
phosphatidylinositol 3-kinase regulatory activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:p85α_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000145675
5295
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:phosphoinositide-3-kinase_regulatory_subunit_1
|
|
gptkbp:function
|
regulatory subunit of phosphoinositide 3-kinase (PI3K)
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
8979
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3R1
|
|
gptkbp:interactsWith
|
gptkb:PIK3CA
gptkb:IRS1
SH2 domain-containing proteins
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:length
|
724 amino acids (p85α isoform)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q13.1
|
|
gptkbp:mutationAssociatedWith
|
nonsense
missense
immunodeficiency
overgrowth syndromes
splice site
|
|
gptkbp:OMIM
|
171833
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3r1
|
|
gptkbp:producesIsoform
|
gptkb:p50α
gptkb:p55α
gptkb:p85α
|
|
gptkbp:regulates
|
PI3K signaling
PIK3CA catalytic activity
|
|
gptkbp:UniProtID
|
gptkb:P27986
|
|
gptkbp:bfsParent
|
gptkb:Class_I_PI3K
|
|
gptkbp:bfsLayer
|
5
|