E2F transcription factor 1

URI: https://gptkb.org/entity/E2F_transcription_factor_1

GPTKB entity

Statements (65)

Predicate	Object
gptkbp:instanceOf	gptkb:protein transcription factor
gptkbp:alternativeName	gptkb:transcription_factor_E2F1 gptkb:E2F-1 gptkb:E2F1
gptkbp:biologicalProcess	apoptosis regulation of cell cycle DNA replication DNA binding transcription factor activity
gptkbp:encodedBy	gptkb:E2F1_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000101412 1869
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:gene	gptkb:E2F1
gptkbp:has_disease_association	gptkb:cancer gptkb:glioblastoma gptkb:retinoblastoma prostate cancer
gptkbp:has_GeneCards_ID	GC19P034285
gptkbp:has_length	437 amino acids
gptkbp:has_phosphorylation_site	Serine 364 Serine 403 Threonine 433
gptkbp:has_Reactome_ID	R-HSA-113510
gptkbp:has_RefSeq	gptkb:NP_005216.1
gptkbp:HGNC_ID	3113
https://www.w3.org/2000/01/rdf-schema#label	E2F transcription factor 1
gptkbp:interactsWith	gptkb:DP1 gptkb:p53 gptkb:retinoblastoma_protein
gptkbp:KEGGID	gptkb:hsa:1869
gptkbp:locatedOnChromosome	gptkb:20q11.2 20
gptkbp:molecularWeight	47 kDa
gptkbp:OMIM	189971
gptkbp:orthologIn	gptkb:mouse_E2f1
gptkbp:partOf	gptkb:E2F_family
gptkbp:PDB	1CF7 1H1V
gptkbp:regulates	gptkb:p14ARF gptkb:DNA_polymerase_alpha gptkb:MCM_proteins gptkb:caspase_7 gptkb:p16INK4A gptkb:thymidine_kinase gptkb:topoisomerase_II_alpha gptkb:cyclin_A gptkb:p21 gptkb:p27 gptkb:BCL2 gptkb:cyclin_E gptkb:CDC6 gptkb:caspase_8 gptkb:caspase_9 cell proliferation cell cycle progression G1/S transition of mitotic cell cycle ARF expression p73 expression transcription from RNA polymerase II promoter
gptkbp:subcellularLocation	gptkb:nucleus
gptkbp:UniProtID	gptkb:Q01094
gptkbp:bfsParent	gptkb:E2F1
gptkbp:bfsLayer	7